Vertical growth phase and positive sentinel node in thin melanoma

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Vertical growth phase and positive sentinel node in thin melanoma.

Sentinel node (SN) status is the most important prognostic factor for localized melanoma. Usually, patients with Breslow thickness of less than 1.0 mm are not included in SN protocols. However, the literature presents a rate ranging from 3 to 7% of nodal recurrence in thin melanoma. Ulceration, regression and high mitotic rate have been considered to be indications for an SN biopsy. The metasta...

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Sentinel Lymph Node in Thin and Thick Melanoma.

The recommendation for sentinel lymph node bio psy (SLNB) is a controversial problem in the management of cutaneous malignant melanoma (CMM). Rovere et al. performed a study with the objective to assess the epidemiologic profile of patients with CMM, who underwent SLNB in Blumenau-Santa Caterina region in Brazil [1]. According to ESMO Clinical Practice Guidelines for dia gnosis, treatment and f...

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Sentinel lymph node biopsy in patients with thin melanoma.

OBJECTIVE To define the percentage of positive sentinel lymph node biopsies and identify risk factors for the presence of lymph node disease in patients with melanomas less than or equal to 1 mm in depth. DESIGN Retrospective chart review. SETTING Washington University School of Medicine and Barnes-Jewish Hospital, St Louis, Mo, a melanoma referral center with outpatient surgical care. PA...

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Indications of Sentinel Node Biopsy in Thin Melanoma.

OBJECTIVE To assess data on survival, recurrence and histological factors in positive and negative sentinel lymph nodes in thin melanoma cases. METHODS A systematic review was conducted on observational studies in four databases (Cochrane Library, Medline, Embase and Lilacs). Positive and negative micrometastases in sentinel lymph node biopsy were compared regarding the clinical outcomes - de...

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When sentinel lymph node biopsy (SLNB) for the regional staging of melanoma was first introduced, it was recommended for any patient with a melanoma between 1.0 and 4.0 mm in Breslow thickness. Patients with thin melanomas were not felt to have a sufficiently high risk to warrant the additional cost and morbidity of the procedure. As experience grew, several retrospective series identified risk...

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ژورنال

عنوان ژورنال: Brazilian Journal of Medical and Biological Research

سال: 2003

ISSN: 0100-879X

DOI: 10.1590/s0100-879x2003000300009